GCSF PRP

Understanding The G-CSF In Detail For IVF And Other Treatments

Medical sciences have developed in many ways; couples who fail to conceive can use medical treatments to become parents. The first option that comes to mind is IVF. However, there are many factors that IVF needs to be successful. Many advanced treatments, such as PRP, sequential transfer, Egg Oocyte Freezing, etc., help enhance the success rate of IVF, one of them being the G-CSF. These advanced treatments ensure you have better chances to conceive.

G-CSF, also called filgrastim, is a drug that is used to produce white blood cells when it's below normal in the body. This treatment also helps in embryo transfer during IVF, which many doctors suggest depending on assessment by the clinic. Let us understand what is granulocyte colony stimulating factor is in detail:

What is G-CSF (Granulocyte Colony-Stimulating Factor)?

G-CSF(Granulocyte Colony Stimulating Factor) is a protein that can help your body make neutrophils, which are white blood cells. G-CSF is used to improve the receptivity of the inner lining of the uterus called the endometrium. It is used for patients who have thin linings leading to failed implantation. The G-CSF is inserted into the uterus or is given subcutaneously before single embryo transfer, which helps in better implantation. Usually, 1 or 2 intrauterine applications of G-CSF are given. If there is still a problem of thin endometrium and failed implantation, PRP (Platelet Rich Plasma) Treatment is given. A 30ml blood drawn from a patient is processed in an FDA-approved device from which 3 to 4 ml PRP is extracted. The extracted PRP is instilled into the uterine cavity.

G-CSF and IVF Treatment 

The pegylated recombinant human granulocyte colony stimulating factor is used in IVF treatment to enhance embryo implantation and the continuation of pregnancy. Those couples who have multiple IVF failures are suggested to have GSCF in their IVF treatment, as it helps in thickening the endometrial. The G-CSF in the treatment works in different ways to support IVF, such as: 

  • Increased blood supply: The G-CSF promotes regenerative activity in cells and helps in increasing blood supply in the endometrium.
  • Increased endometrial receptivity: The G-CSF is used to improve the receptivity of the inner lining of the uterus. It also helps in the successful treatment of implantation. 
  • Promoting regenerative activity: The G-CSF encourages regenerative activities among endometrial cells. 

What are the Various Factors Considered by Doctors for G-CSF?

When G-CSF is suggested for any patient, there are various factors that doctors check. It helps to identify the level of risk and success in patients after G-CSF. Here are some of the conditions that doctors consider: 

  • Your age.
  • Your health and previous medication.
  • In the case of IVF treatment, how many IVF failures have occurred. 
  • If G-CSF has any effect after IVF treatment previously 

Patients can consider the cost of G-CSF and other details. 

What is the Procedure for G-CSF?

The G-CSF procedure has certain steps that you need to know. Here's what you can expect: 

  • Doctors will conduct an assessment test to understand your medications, medical history, and other details to know if taking G-CSF is safe or not. 
  • You need to provide details of your past or present conditions and any medications or supplements you are taking. 
  • Once it is confirmed that your doctor suggests G-CSF, the process will take place. 
  • You will get injected with a G-CSF shot under your skin, or you will get it through an IV drip, depending on the medical setting. 
  • You will share any discomfort or symptoms you are facing, though it's not necessary you have discomfort after the G-CSF injection.

Why Choose Bloom IVF for your Fertility Treatments?

There are very few clinics that have options for the latest technology and treatment; Bloom IVF is one of them. Bloom IVF is known as one of the best fertility clinics in India. We offer many benefits for patients to choose us for treatments, such as:

  • Diagnosis and Treatment: We use the latest technology to diagnose and treat various fertility issues. Our clinic has the latest equipment to help you with high-accuracy and effective diagnosis options. These include luteal phase, embryoscope, and more.
  • Expertise: We have experienced fertility experts to help you with your issues. We take patients' assessments before proceeding. Our doctors will provide you with counseling and consultation to answer queries and proceed with treatments like sperm retrieval, PRP, PCOS, blastocyst culture, and more.
  • Affordability: We understand fertility treatments can be expensive, so we ensure our patients worry about their health, not their bills. We have affordable packages for fertility treatments and provide a heads-up beforehand. We offer affordable peg G-CSF 6mg injection price and G-CSF price.
  • Accuracy: We suggest treatments as per the assessment, such as timed intercourse, Spindle Check, and more. Our doctors will suggest treatments that suit you best for a high success rate based on your conditions.
  • Success rate: We do not suggest treatments unless we identify there are chances of success rate. Our team will conduct thorough research to understand the chances. To enhance the success rate, we also recommend additional treatments like magnetic activated cell sorting

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Step-by-Step Procedure of GCSF

1
The GCSF injection can be given under the skin or can be instilled inside the endometrial cavity using a atraumatic cannula
2
The intrauterine gcsf is instilled around the time of embryo transfer
3
The subcutaneous injection can be given shortly after the embryo transfer

Common Questions

If you could not find an answer to your query, please contact us.

G-CSF is used for patients with some types of cancers and Neutropenia because of some type of chemotherapy. It also helps in IVF treatment and autologous stem cell transplant and helps bone marrow to make more white blood cells.
G-CSF in IVF treatment is used to enhance the endometrial thickness, which helps in the successful implantation of embryos for conception.
It is said that G-CSF has a vital function in ovulation, follicular maturation, implantation, and pregnancy after conception. The uterine epithelial cell G-CSF expression is high for a few days because of the progesterone effect and its level decline around embryo transfer.
As per studies, G-CSF during pregnancy is safe and tolerated. However, you have to discuss it with your fertility expert in detail.
G-CSF is a growth factor that helps produce more white blood cells to reduce the infection risk after some types of cancer treatments. It also helps make stem cells that move from bone marrow to blood.
It takes around several days or a week for G-CSF to work. Some people, after chemotherapy, continue to take G-CSF until their blood cell level returns to normal.